The Ender 3 clones already have pretty good resolution on the x and y axes, so I don’t think that the extra 20% resolution will make much visible difference. Having said that though, I don’t think it will hurt, and I’m all for tinkering for tinkering’s sake, so I say go for it Let us know how it goes!
You have to consider the complete impact of 20 → 16
Precision +20%
Torque -20% (means your motor needs to work less)
Speed -20% (means your motor needs to rotate 20% faster for the same printing speed)
In addition there are additional effects that are harder to quantify, like the quality how the belt is guided (should be better with a larger diameter pulley) etc.
Likely a bit of a philosophical question. Since you can increase the resolution with microstepping and / or 0.9° stepper, I’d rather stick to 20 teeth pulley.