@HoltiWilan
Check out this document on how to setup the Slicer: X-In/1-Out Non-Mixing Extruder - Automate SuperSlicer & PrusaSlicer Filament Swaps
Although I’ve created the documentation using SuperSlicer, setting up Prusa Slicer is very similar.
Regarding your issue on Pressure Advance, that is in your Slicer Tool Change customer G-Code. I’ve put in Pressure Advance strings in each Filament start G-Code as PA can be unique per filament and extruder.
Hope this helps.
-James