Ender 3v2 Neo Custom

Sorry, I missed that.

Yes, your pin layout looks good. Bed and extruder are not heating at all.

Your problem is this
‘mcu’: Unable to open serial port: [Errno 2] could not open port /dev/ttySO: [Errno 2] No such file or directory: ‘/dev/ttySO’

Try to read here How-To Trouble-Shoot
Search for " Connection Problems to the Printer Board"