Make sure that
- you have build and flashed according to klipper/config/generic-bigtreetech-skr-v1.4.cfg at master · Klipper3d/klipper · GitHub, i.e. LPC1769
- you are not affected by Debian Bullseye Bug causing Klipper to no longer find the printer board
- you are not affected by Other Single Board Computers (SBC) apart from Raspberry Pis → last point regarding ModemManager and BRLTTY